9/1/2000 Home vs Landmark Christian Win 24-0
9/8/2000 Home vs Social Circle Win 28-7
9/15/2000 Away at South Forsyth Win 25-22
9/22/2000 Away at Brookstone Win 16-14
- Drew Vlass 2 blocked extra points, 1 blocked field goal and an interception
9/29/2000 Away at Pike County
10/13/2000 Home vs Grayson Win 24-0
- Jake Humphrey caught a 49-yard pass from Zach Young to open the scoring and later added a 45-yard run to lead Wesleyan (6-0, No. 8 in A). Grayson never threatened to score, crossing midfield only twice in the game.
10/20/2000 Away at Madison County Loss 18-28
10/27/2000 Home vs Commerce Loss 10-34
- Monte Williams came 246 yards closer to the state career all-time rushing record Friday, lifting visiting and sixth-ranked Commerce to a 34-10 rout of Wesleyan in a Region 8-A game
11/3/2000 Home vs Buford Loss 0-35
11/10/2000 Away at Jefferson Loss 9-10
11/17/2000 Away at Lincoln County Loss 7-45